2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine

Base Information

• Chemical Name: 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine
• CAS No.: 658066-44-5
• Molecular Formula: C₈H₈ClF₃N₂
• Molecular Weight: 224.613
• Hs Code.: 2933399990
• European Community (EC) Number: 807-092-9
• DSSTox Substance ID: DTXSID00474843
• Nikkaji Number: J3.560.979B
• Wikidata: Q82304982
• Mol file: 658066-44-5.mol

Synonyms:658066-44-5;2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine;2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine;2-(3-Chloro-5-(trifluoromethyl)-pyridin-2-yl)ethanamine;2-[3-Chloro-5-(trifluoromethyl)-2-pyridyl]ethanamine;2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethan-1-amine;2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethan-1-amine;2-(3-CHLORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-ETHYLAMINE;2-Pyridineethanamine, 3-chloro-5-(trifluoromethyl)-;SCHEMBL1122017;AMY3388;DTXSID00474843;MFCD11848345;AKOS016012941;AB64799;AS-69621;CS-0201438;J3.560.979B;EN300-132680;A867589;2-(3-chloro-5-trifluormethyl-pyridin-2-yl)-ethylamine;2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]ethanamine;2-(3-Chloro-5-(trifluoromethyl) pyridin-2-yl)ethanamine;2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-ethylamine

Chemical Property of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine

Chemical Property:

• Boiling Point: 230.5±35.0 °C(Predicted)
• PKA: 8.20±0.10(Predicted)
• Density: 1.364±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 224.0328104
• Heavy Atom Count: 14
• Complexity: 186

Purity/Quality:

98% ^*data from raw suppliers

2-(2-Aminoethyl)-3-chloro-5-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)CCN)C(F)(F)F

Technology Process of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine

There total 7 articles about 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-chloro-5-(trifluoromethyl)-2-ethylacetamide-pyridinyl → 2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-1-ethanamine (658066-44-5)

Guidance literature:

With hydrogenchloride; In water; for 5h; Product distribution / selectivity; Heating / reflux;

Reference yield: 76.59%

2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile (157764-10-8) → 2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-1-ethanamine (658066-44-5)

Guidance literature:

With hydrogen; In tert-butyl methyl ether; at 25 ℃; for 4h; under 15001.5 Torr; Autoclave;

Reference yield:

2-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethyl)isoindoline-1,3-dione → 2-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-1-ethanamine (658066-44-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 3h;

upstream raw materials:

2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

diethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)malonate

2,3-dichloro-5-trifluoromethylpyridine

ethyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-cyanoacetate

Downstream raw materials:

fluopyram