2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile

Base Information

Chemical Name:2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile
CAS No.:157764-10-8
Molecular Formula:C8H4ClF3N2
Molecular Weight:220.581
Hs Code.:2933399090
European Community (EC) Number:696-141-6
DSSTox Substance ID:DTXSID80585401
Wikidata:Q82477359
Mol file:157764-10-8.mol

Synonyms:157764-10-8;2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile;[3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile;2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile;2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-acetonitrile;(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-acetonitrile;MFCD08444379;2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile;SCHEMBL784481;3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-ACETONITRILE;DTXSID80585401;AKOS015848642;AB45261;FE-0718;SY168900;CS-0215502;EN300-25462;F83075;J-505771;(3-chloro-5-trifluormethyl-pyridin-2-yl)-acetonitrile;2-Pyridineacetonitrile, 3-chloro-5-(trifluoromethyl)-;[3-chloro-5-(trifluoromethyl)-2-pyridinyl] acetonitrile;[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile;2-[3-Chloro-5-(trifluoromethyl)-2-pyridyl]acetonitrile

Suppliers and Price of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Chloro-5-(trifluoromethyl)-2-pyridineacetonitrile
1g
$ 160.00

SynQuest Laboratories
[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile
5 g
$ 407.00

SynQuest Laboratories
[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile
10 g
$ 685.00

SynQuest Laboratories
[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile
1 g
$ 160.00

Matrix Scientific
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-acetonitrile >95%
1g
$ 154.00

Matrix Scientific
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-acetonitrile >95%
250mg
$ 65.00

Matrix Scientific
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-acetonitrile >95%
5g
$ 500.00

Crysdot
2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile 95+%
5g
$ 475.00

Chemenu
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-acetonitrile 95%
5g
$ 449.00

Atlantic Research Chemicals
2-[3-Chloro-5-(trifluoromethyl)-2-pyridyl]acetonitrile 95%
5gm:
$ 219.14

Total 23 raw suppliers

Chemical Property of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile

Chemical Property:

Boiling Point:245.7±35.0 °C(Predicted)
PKA:-1.55±0.32(Predicted)
PSA：36.68000
Density:1.429±0.06 g/cm3(Predicted)
LogP:2.81988
Storage Temp.:2-8°C
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:220.0015103
Heavy Atom Count:14
Complexity:245

Purity/Quality:

98% ^*data from raw suppliers

3-Chloro-5-(trifluoromethyl)-2-pyridineacetonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=NC(=C1Cl)CC#N)C(F)(F)F
Uses 3-Chloro-5-(trifluoromethyl)-2-pyridineacetonitrile is used in the preparation of (pyridyl)pyrazolopyrimidines as corticotropin-releasing factor receptor antagonists.

Technology Process of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile

There total 7 articles about 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 75-05-8,26809-02-9
acetonitrile

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Guidance literature:: With sodium methylate; at 130 ℃; for 16h; under 21002.1 Torr; Pressure; Temperature; Reagent/catalyst; Inert atmosphere;

Reference yield: 94.0%

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 105-56-6
ethyl 2-cyanoacetate

: 157764-10-8
2‐[3‐chloro‐5‐(trifluoromethyl)pyridin‐2‐yl]acetonitrile

Guidance literature:: 2,3-dichloro-5-trifluoromethylpyridine; ethyl 2-cyanoacetate; With potassium hydroxide; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 3h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; at 130 ℃; for 2h; pH=2;