(2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid

Base Information

• Chemical Name: (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid
• CAS No.: 135632-49-4
• Molecular Formula: C₂₀H₃₀N₂O₆S
• Molecular Weight: 426.534

Synonyms:(2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid

Chemical Property of (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid

Chemical Property:

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Technology Process of (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid

There total 4 articles about (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.9%

benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate (150544-85-7) → (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid (135632-49-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 760 Torr;

DOI:10.1021/jm00071a009

Reference yield:

(piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid (135632-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Et₃N / CH₂Cl₂ / 0.25 h / -10 °C

2: 61.9 percent / H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm00071a009

Reference yield:

2-Benzyloxycarbonyl-3-phenyl-1-propylsulfonyl Chloride (128117-17-9) → (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionic acid (135632-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Et₃N / CH₂Cl₂ / 0.25 h / -10 °C

2: 61.9 percent / H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm00071a009

upstream raw materials:

benzyl (2RS)-2-benzyl-3-<piperidinyl>>sulfonyl>propionate

(piperidin-4-yl)carbamic acid tert-butyl ester

2-Benzyloxycarbonyl-3-phenyl-1-propylsulfonyl Chloride

Downstream raw materials:

[1-((S)-2-{(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethylcarbamoyl}-3-phenyl-propane-1-sulfonyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

(1-{(S)-2-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-3-phenyl-propane-1-sulfonyl}-piperidin-4-yl)-carbamic acid tert-butyl ester

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