5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Base Information

Chemical Name:5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
CAS No.:1262860-41-2
Molecular Formula:C₁₁H₁₀F₃N₃O₃
Molecular Weight:289.214
Hs Code.:

Synonyms:5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Chemical Property of 5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Technology Process of 5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

There total 11 articles about 5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262860-40-1
5-difluoromethyl-5-(2-fluoro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

: 1262860-41-2
5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: With sulfuric acid; potassium nitrate; at 22 ℃; for 1h;

Reference yield:

: 1262859-00-6
N-[1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

: 1262860-41-2
5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 3 h / Reflux

2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / methanol / 1 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 1 h / 68 °C

4.1: ammonia / methanol

4.3: Cooling with ice

5.1: potassium nitrate; sulfuric acid / 1 h / 22 °C

5.2: pH 12 - 14 / Cooling with ice

With Lawessons reagent; sulfuric acid; potassium tert-butylate; ammonia; hydrogen; sodium acetate; potassium nitrate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tert-butyl alcohol;

Reference yield:

: 1262859-02-8
5-(5-bromo-2-fluorophenyl)-5-(difluoromethyl)morpholin-3-one

: 1262860-41-2
5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; sodium acetate / palladium 10% on activated carbon / methanol / 1 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 1 h / 68 °C

3.1: ammonia / methanol

3.3: Cooling with ice

4.1: potassium nitrate; sulfuric acid / 1 h / 22 °C

4.2: pH 12 - 14 / Cooling with ice

With Lawessons reagent; sulfuric acid; ammonia; hydrogen; sodium acetate; potassium nitrate; palladium 10% on activated carbon; In tetrahydrofuran; methanol;