[5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester
CAS No.:1262860-42-3
Molecular Formula:C₁₆H₁₈F₃N₃O₅
Molecular Weight:389.331
Hs Code.:

Synonyms:[5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

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Chemical Property of [5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

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Technology Process of [5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

There total 13 articles about [5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1262860-41-2
5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

: 1262860-42-3
[5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 - 60 ℃;

Reference yield:

: BOC anhydride

: 1262860-41-2
5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

: 144-55-8
sodium hydrogencarbonate

: 1262860-42-3
[5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogenchloride; DIPEA; In tetrahydrofuran;

Reference yield:

: 1262859-00-6
N-[1-(5-bromo-2-fluoro-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloro-acetamide

: 1262860-42-3
[5-Difluoromethyl-5-(2-fluoro-5-nitro-phenyl)-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 3 h / Reflux

2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / methanol / 1 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 1 h / 68 °C

4.1: ammonia / methanol

4.3: Cooling with ice

5.1: potassium nitrate; sulfuric acid / 1 h / 22 °C

5.2: pH 12 - 14 / Cooling with ice

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 82 h / 20 - 60 °C

With Lawessons reagent; sulfuric acid; potassium tert-butylate; ammonia; hydrogen; sodium acetate; potassium nitrate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tert-butyl alcohol;