Technology Process of (2R,3S)-3-hydroxy-2-(2-phenethyloxyethoxy-carbonylamino)-butanoic acid
There total 3 articles about (2R,3S)-3-hydroxy-2-(2-phenethyloxyethoxy-carbonylamino)-butanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,2'-dipyridyl carbonate; (2-Hydroxyethyl)phenylethyl ether;
With
dmap;
In
dichloromethane;
at 20 ℃;
for 15h;
Inert atmosphere;
D-Threonine;
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 15h;
DOI:10.1021/jm400739u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 60 °C / Inert atmosphere
1.2: 3 h / 80 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / diethyl ether / 4 h / 20 °C / Inert atmosphere
3.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere
3.2: 15 h / 20 °C
With
dmap; lithium aluminium tetrahydride; sodium hydride;
In
diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm400739u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 4 h / 20 °C / Inert atmosphere
2.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere
2.2: 15 h / 20 °C
With
dmap; lithium aluminium tetrahydride;
In
diethyl ether; dichloromethane;
DOI:10.1021/jm400739u