74121-91-8

Upstream product

• 75-21-8 oxirane 
• 60-12-8 2-phenylethanol 
• 81228-03-7 2-phenethyloxyacetic acid 
• 540-51-2 2-bromoethanol 
• 101-49-5 2-(benzyl)-1,3-dioxolane 
• 1046818-42-1 tert-butyl 2-phenethoxyacetate 

Downstream Products

• 948893-87-6 1-phenethyloxy-2-(toluene-4-sulfonyloxy)-ethane 
• 122-78-1 phenylacetaldehyde 
• 90875-09-5 (2-Bromoethyl)phenylethyl ether 
• 321901-46-6 p-(2-Bromoethyl)styrylethyl ether 
• 321901-45-5 (2-Bromoethyl)acetophenethyl ether 
• 86902-17-2 2-<<2-(4-nitrophenyl)ethyl>oxy>ethanol 
• 86902-19-4 4-<2-(2-hydroxyethoxy)ethyl>benzonitrile 
• 86902-16-1 2-<<2-(2-nitrophenyl)ethyl>oxy>ethanol 
• 81227-91-0 4-<2-<(2-phenylethyl)oxy>ethoxy>-2-cresol 
• 344438-39-7 Methanesulfonic acid 2-[2-(4-cyano-phenyl)-ethoxy]-ethyl ester 
• 81228-24-2 2-chloro-4-<2-<(2-phenylethyl)oxy>ethoxy>phenol 
• 81227-98-7 2'-methyl-4'-<2-<(2-phenylethyl)oxy>ethoxy>acetophenone 
• 81227-97-6 1-(benzyloxy)-2-chloro-4-<2-<(2-phenylethyl)oxy>ethoxy>benzene 
• 344407-82-5 2-<<2-(4-aminophenyl)ethyl>oxy>ethanol 

Relevant academic research and scientific papers

Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp3)-H Functionalization under Mild Reaction Conditions

Reported herein is the first visible-light-induced formation of alkoxyl radicals from N-alkoxyphthalimides, and the Hantzsch ester as the reductant is crucial for the reaction. The selective hydrogen atom abstraction by the alkoxyl radical enables C(sp3)-H allylation and alkenylation reactions under mild reaction conditions at room temperature. Broad substrate variations, including a structurally complexed steroid, undergo the C(sp3)-H functionalization reaction effectively with high regio- and chemoselectivity.

Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA)

The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.

Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3- oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors

N-Acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of endogenous lipid agonists of peroxisome proliferator-activated receptor-α, which include oleoylethanolamide (OEA) and palmitoylethanolamide (PEA). The β-lactone derivatives (S)-N-(2-oxo-3-oxetanyl)-3-phenylpropionamide (2) and (S)-N-(2-oxo-3-oxetanyl)- biphenyl-4-carboxamide (3) inhibit NAAA, prevent FAE hydrolysis in activated inflammatory cells, and reduce tissue reactions to pro-inflammatory stimuli. Recently, our group disclosed ARN077 (4), a potent NAAA inhibitor that is active in vivo by topical administration in rodent models of hyperalgesia and allodynia. In the present study, we investigated the structure-activity relationship (SAR) of threonine-derived β-lactone analogues of compound 4. The main results of this work were an enhancement of the inhibitory potency of β-lactone carbamate derivatives for NAAA and the identification of (4-phenylphenyl)-methyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]carbamate (14q) as the first single-digit nanomolar inhibitor of intracellular NAAA activity (IC50 = 7 nM on both rat NAAA and human NAAA).

DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA)

The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.

OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES

A quaternary ammonium compound of formula (I) having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.

AGONISTS OF THE SPHINGOSINE- 1- PHOSPHATE RECEPTOR (SLP)

The invention provides compounds of formula I and formula II, their preparation, a their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SlP receptors.

PHENETHANOLAMINE DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS

The present invention relates to compounds according to formula (I), a process for preparing them, the intermediate compounds of the process and the use of the compounds in the manufacture of a medicament for use in treating diseases such as ARDS, pulmonary emphysema, bronchitis, bronchiectasis, COPD, asthma and rhinitis. The compounds are beta2 adrenoreceptor agonists.

Reductive cleavage of the C-O bond of acetals and orthoesters: Reduction by silane in the presence of a Rh-PPh3 complex

Reductions of acetals to ethers and of orthoester to acetal by hydrosilane using rhodium catalyst are described.

Stamping of monomeric SAMs as a route to structured crystallization templates: Patterned titania films

Gold-coated glass slides have be patterned by using self-assembled monolayers (SAM) of alkane thiols. Through the use of a special thiol terminated with a styrene monomer, microstructures of 5 to 10 μm width and 70 A height have been formed on the surface

Ethoxylation of aralkyl alcohols

An important reaction, the oligoaddition of ethylene oxide to the alcoholic hydroxyl group was investigated.The aralkyl alcohols were chosen as base material: benzyl-, β-phenylethyl- and γ-phenylpropyl alcohols.The first members of their homologue ethoxylated series were prepared and used as standards for the determination of the average degree of ethoxylation (IR, UV, refractive indices) and of the molar mass distribution (HPLC).