(3R,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester; compound with picric acid

Base Information

Chemical Name:(3R,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester; compound with picric acid
CAS No.:75373-49-8
Molecular Formula:C₆H₃N₃O₇*C₁₈H₂₃NO₂
Molecular Weight:514.492
Hs Code.:

Synonyms:(3R,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester; compound with picric acid

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Chemical Property of (3R,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester; compound with picric acid

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Technology Process of (3R,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester; compound with picric acid

There total 2 articles about (3R,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester; compound with picric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1552-92-7
ethyl cyclohexylideneacetate

: 50917-73-2
diethyl N-(benzylidene)-aminomethylphosphonate

: 75373-49-8
(3R,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester; compound with picric acid

: (1R,3R,4S)-1-(Diethoxy-phosphoryl)-3-phenyl-2-aza-spiro[4.5]decane-4-carboxylic acid ethyl ester; compound with picric acid

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -72 - -10 ℃;

Reference yield:

: 100-52-7
benzaldehyde

: 75373-49-8
(3R,4S)-3-Phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid ethyl ester; compound with picric acid

Guidance literature:: Multi-step reaction with 2 steps

1: benzene

2: 30 percent / LDA / tetrahydrofuran / -72 - -10 °C

With lithium diisopropyl amide; In tetrahydrofuran; benzene;