(3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol

Base Information

• Chemical Name: (3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol
• CAS No.: 164981-01-5
• Molecular Formula: C₂₁H₂₆O₃
• Molecular Weight: 326.436
• Mol file: 164981-01-5.mol

Synonyms:(3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol

Chemical Property of (3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol

There total 3 articles about (3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-butyl(triphenyl)phosphonium bromide (1779-51-7) + 4-bromo-benzaldehyde (1122-91-4) + 3-(dimethoxymethyl)benzaldehyde (100501-45-9) → (3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol (164981-01-5) + (3-dimethoxymethylphenyl)-(4-pent-1-enylphenyl)methanol

Guidance literature:

n-butyl(triphenyl)phosphonium bromide; 4-bromo-benzaldehyde; With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -80 ℃; for 1.5h;

3-(dimethoxymethyl)benzaldehyde; With sec.-butyllithium; In tetrahydrofuran; at -80 ℃;

DOI:10.1016/S0040-4039(02)01056-0

Reference yield:

Isophthalaldehyde (626-19-7) → (3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol (164981-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / NH₄NO₃ / methanol / 2 h / Heating

2.1: 88 percent / SiO₂; aq. H₂SO₄ / CH₂Cl₂ / 0.75 h / 20 °C

3.1: nBuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / 1.5 h / -80 °C

3.2: secBuLi / tetrahydrofuran / -80 °C

With ammonium nitrate; n-butyllithium; sulfuric acid; silica gel; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;

DOI:10.1016/S0040-4039(02)01056-0

Reference yield:

isophthalaldehyde bis-dimethylacetal (37832-33-0) → (3-Dimethoxymethyl-phenyl)-[((Z)-4-pent-1-enyl)-phenyl]-methanol (164981-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 88 percent / SiO₂; aq. H₂SO₄ / CH₂Cl₂ / 0.75 h / 20 °C

2.1: nBuLi / hexamethylphosphoric acid triamide; tetrahydrofuran / 1.5 h / -80 °C

2.2: secBuLi / tetrahydrofuran / -80 °C

With n-butyllithium; sulfuric acid; silica gel; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;

DOI:10.1016/S0040-4039(02)01056-0

upstream raw materials:

n-butyl(triphenyl)phosphonium bromide

4-bromo-benzaldehyde

3-(dimethoxymethyl)benzaldehyde

Isophthalaldehyde

Downstream raw materials:

tert-butyl-[(3-dimethoxymethyl-phenyl)-(4-pent-1-enyl-phenyl)-methoxy]-dimethyl-silane

Methyl(5Z)-6-{3-[hydroxy-(4-pentylphenyl)methyl]phenyl}hex-5-enoate

(Z)-6-(3-{Hydroxy-[((Z)-4-pent-1-enyl)-phenyl]-methyl}-phenyl)-hex-5-enoic acid methyl ester

3-[(tert-butyl-dimethyl-silanyloxy)-(4-pent-1-enyl-phenyl)-methyl]-benzaldehyde