PROPYL-(4-TRIFLUOROMETHYL-PHENYL)-AMINE

Base Information

• Chemical Name: PROPYL-(4-TRIFLUOROMETHYL-PHENYL)-AMINE
• CAS No.: 190843-72-2
• Molecular Formula: C10H12 F3 N
• Molecular Weight: 203.2
• Mol file: 190843-72-2.mol

Synonyms:PROPYL-(4-TRIFLUOROMETHYL-PHENYL)-AMINE

Chemical Property of PROPYL-(4-TRIFLUOROMETHYL-PHENYL)-AMINE

Chemical Property:

• PSA: 12.03000
• LogP: 3.60030

Purity/Quality:

Propyl-(4-trifluoromethyl-phenyl)-amine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PROPYL-(4-TRIFLUOROMETHYL-PHENYL)-AMINE

There total 3 articles about PROPYL-(4-TRIFLUOROMETHYL-PHENYL)-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-trifluoromethylphenylamine (455-14-1) + propionaldehyde (123-38-6) → N-propyl-4-(trifluoromethyl)benzenamine (190843-72-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 18 ℃; for 0.0833333h; Solvent; Green chemistry;

DOI:10.1039/c3gc40359a

Reference yield: 86.0%

propylamine (107-10-8,42939-71-9) + p-trifluoromethylphenyl bromide (402-43-7) → N-propyl-4-(trifluoromethyl)benzenamine (190843-72-2)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; nickel(II) bromide 2-methoxyethy ether complex; 3,7-di([1,1′-biphenyl]-4-yl)-10-(naphthalen-1-yl)-10H-phenoxazine; In N,N-dimethyl acetamide; at 60 ℃; for 24h; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1002/chem.201702926

Reference yield: 86.0%

→ N-propyl-4-(trifluoromethyl)benzenamine (190843-72-2)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; nickel(II) bromide dimethoxyethane; 5,10-di(4-cyanophenyl)-5,10-dihydrophenazine; In N,N-dimethyl acetamide; at 25 - 60 ℃; for 24h; Irradiation;

upstream raw materials:

4-trifluoromethylphenylamine

propionaldehyde

propylamine

p-trifluoromethylphenyl bromide

Refernces

• 1、 Kudisch, Max,Lim, Chern-Hooi,Thordarson, Pall,Miyake, Garret M.. "Energy Transfer to Ni-Amine Complexes in Dual Catalytic, Light-Driven C-N Cross-Coupling Reactions". supporting information. p. 19479 - 19486. Retrieved 2019/12/25.
• 2、 Lim, Chern-Hooi,Kudisch, Max,Liu, Bin,Miyake, Garret M.. "C-N Cross-Coupling via Photoexcitation of Nickel-Amine Complexes". supporting information. p. 7667 - 7673. Retrieved 2018/05/31.