(2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one

Base Information

Chemical Name:(2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one
CAS No.:1187433-87-9
Molecular Formula:C₂₃H₂₉FO₄Si
Molecular Weight:416.565
Hs Code.:

Synonyms:(2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one

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Chemical Property of (2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one

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Technology Process of (2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one

There total 5 articles about (2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187433-86-8
(2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol

: 1187433-87-9
(2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2010.07.017

Reference yield:

: 874638-80-9,1033394-94-3
((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

: 1187433-87-9
(2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / -10 - 0 °C

2: boron trifluoride diethyl etherate / 20 - 80 °C

3: ammonia / 36 h / 20 °C

4: 1H-imidazole / dichloromethane / 0 - 20 °C

5: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; boron trifluoride diethyl etherate; ammonia; Dess-Martin periodane; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1187433-85-7
(2R,3R,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxy-4-methyl-tetrahydrofuran-3-ol

: 1187433-87-9
(2R,4S)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-dihydrofuran-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; Dess-Martin periodane; In dichloromethane;