(2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol

Base Information

Chemical Name:(2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol
CAS No.:1187433-86-8
Molecular Formula:C₂₃H₃₁FO₄Si
Molecular Weight:418.581
Hs Code.:

Synonyms:(2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol

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Chemical Property of (2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol

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Technology Process of (2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol

There total 3 articles about (2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1187433-85-7
(2R,3R,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxy-4-methyl-tetrahydrofuran-3-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1187433-86-8
(2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2010.07.017

Reference yield:

: 874638-80-9,1033394-94-3
((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

: 1187433-86-8
(2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / -10 - 0 °C

2: boron trifluoride diethyl etherate / 20 - 80 °C

3: ammonia / 36 h / 20 °C

4: 1H-imidazole / dichloromethane / 0 - 20 °C

With 1H-imidazole; boron trifluoride diethyl etherate; ammonia; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1187433-84-6
(2R,3R,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxy-4-methyltetrahydrofuran-3-yl benzoate

: 1187433-86-8
(2R,3R,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-4-methyl-tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / 36 h / 20 °C

2: 1H-imidazole / dichloromethane / 0 - 20 °C

With 1H-imidazole; ammonia; In dichloromethane;