ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride

Base Information

• Chemical Name: ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride
• CAS No.: 82128-77-6
• Molecular Formula: C₁₀H₁₂FNO₂*ClH
• Molecular Weight: 233.67
• Mol file: 82128-77-6.mol

Synonyms:ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride

Chemical Property of ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride

There total 3 articles about ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethanol (64-17-5) + α-[(trimethylsilyl)oxy]-α-(o-fluorophenyl)acetonitrile (82128-76-5) → ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride (82128-77-6)

Guidance literature:

With hydrogenchloride; at 5 ℃; for 16h;

DOI:10.1021/jm00155a030

Reference yield:

2-Fluorobenzaldehyde (446-52-6) → ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride (82128-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ZnI₂ / CH₂Cl₂ / 65 h / Ambient temperature

2: 89 percent / HCl / 16 h / 5 °C

With hydrogenchloride; zinc(II) iodide; In dichloromethane;

DOI:10.1021/jm00155a030

Reference yield:

→ ethyl 1-(2-fluorophenyl)-1-hydroxymethanecarboximidate hydrochloride (82128-77-6)

Guidance literature:

upstream raw materials:

ethanol

α-[(trimethylsilyl)oxy]-α-(o-fluorophenyl)acetonitrile

2-Fluorobenzaldehyde

Downstream raw materials:

5-(2-fluorophenyl)oxazolidine-2,4-dione