tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

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Chemical Name:tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate
CAS No.:1092444-60-4
Molecular Formula:C₃₀H₄₇N₅O₃Si
Molecular Weight:553.82
Hs Code.:

Synonyms:tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

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Chemical Property of tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

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Technology Process of tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

There total 8 articles about tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1092444-33-1
benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester

: 115306-75-7
3-(tertbutyldimethylsiloxyl)propylamine

: 1092444-60-4
tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: benzyl (5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamic acid tert-butyl ester; With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 0.0833333h;

3-(tertbutyldimethylsiloxyl)propylamine; In toluene; at 100 ℃; for 12h;

Reference yield:

: 625-28-5
Isovaleronitrile

: 1092444-60-4
tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C

1.2: 16.5 h / -78 - 20 °C

1.3: pH 3

2.1: acetic acid; hydrazine / ethanol / 16 h / Heating / reflux

3.1: sodium / ethanol / 16 h / Heating / reflux

3.2: pH 3

4.1: trichlorophosphate / 16 h / Heating / reflux

5.1: ethanol / 3 h / Heating / reflux

6.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

7.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

7.2: 12 h / 100 °C

With sodium; acetic acid; sodium t-butanolate; hydrazine; lithium diisopropyl amide; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 771510-25-9
3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol

: 1092444-60-4
tert-butyl benzyl(5-(3-(tert-butyldimethylsilyloxy)propylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 16 h / Heating / reflux

2.1: ethanol / 3 h / Heating / reflux

3.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

4.2: 12 h / 100 °C

With sodium t-butanolate; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; toluene;