2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate

Base Information

Chemical Name:2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate
CAS No.:238746-24-2
Molecular Formula:C₁₉H₂₆Cl₃NO₅
Molecular Weight:454.778
Hs Code.:

2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-<tert-butoxycarbonyl-(N)-methylamino>butanoate

Synonyms:2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate

Chemical Property:

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Technology Process of 2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate

There total 1 articles about 2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 115-20-8
1,1,1-trichloroethanol

: 64263-80-5
N-Boc-N-methyl-O-benzyl-L-threonine

: 238746-24-2
2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/ja9811243

Reference yield: 100.0%

: 238746-24-2
2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate

: 238746-25-3
2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-(N)-methylaminobutanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1.5h;
DOI:10.1021/ja9811243

Reference yield:

: 238746-24-2
2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate

: (4R,2'S,3'R)-4-amino-5-methoxycarbonylpentanoyl-3'-benzyloxy-2'-(N)-methylaminobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / TFA / CH₂Cl₂ / 1.5 h

2: 48 percent / DIPEA, BOP reagent / acetonitrile

3: 60 percent / Zn, 90 percent aq. AcOH

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; In dichloromethane; acetonitrile;
DOI:10.1021/ja9811243