(S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

Base Information

• Chemical Name: (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate
• CAS No.: 125150-39-2
• Molecular Formula: C₃₀H₃₆N₂O₄
• Molecular Weight: 488.627
• Mol file: 125150-39-2.mol

Synonyms:(S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

Chemical Property of (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

There total 3 articles about (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S)-2-hydroxy-3-methylbutyric acid benzyl ester (65138-05-8) + 4-(5-n-heptylpyrimidin-2-yl)-benzoic acid (59855-01-5) → (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate (125150-39-2)

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In dichloromethane; for 6h; Ambient temperature;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate (125150-39-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaNO₂, 0.5 M H₂SO₄, 2.) NaOH / 1.) water, -2-0 deg C, 3 h, overnight, room temp., 2.) water, pH=4.5-5.0

2: 96 percent / dimethylformamide / 24 h / Ambient temperature

3: 88 percent / DCC, 4-(N-pyrrolidino)pyridine / CH₂Cl₂ / 6 h / Ambient temperature

With sodium hydroxide; sulfuric acid; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(S)-(-)-sodium 2-hydroxy-3-methylbutanoate (54641-19-9) → (S)-1-(benzyloxycarbonyl)-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate (125150-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / dimethylformamide / 24 h / Ambient temperature

2: 88 percent / DCC, 4-(N-pyrrolidino)pyridine / CH₂Cl₂ / 6 h / Ambient temperature

With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(S)-2-hydroxy-3-methylbutyric acid benzyl ester

4-(5-n-heptylpyrimidin-2-yl)-benzoic acid

L-valine

(S)-(-)-sodium 2-hydroxy-3-methylbutanoate

Downstream raw materials:

(S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

(S)-1-carboxy-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate