3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

Base Information

• Chemical Name: 3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one
• CAS No.: 1380517-42-9
• Molecular Formula: C₁₆H₁₁N₅OS
• Molecular Weight: 321.362
• Mol file: 1380517-42-9.mol

Synonyms:3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

Chemical Property of 3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

There total 6 articles about 3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C16H13N5O2S (1380517-38-3) → 3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one (1380517-42-9)

Guidance literature:

With sodium hydroxide; at 100 ℃; for 1h;

DOI:10.1080/10426507.2011.643433

Reference yield:

2-aminopyridine (504-29-0) → 3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one (1380517-42-9)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 4 h / Reflux

2: polyphosphoric acid (PPA) / 0.5 h / thermal cyclization

3: hydrazine hydrate / ethanol / 3 h

4: ethanol / Reflux

5: sodium hydroxide / 1 h / 100 °C

With hydrazine hydrate; sodium hydroxide; In ethanol;

DOI:10.1080/10426507.2011.643433

Reference yield:

4-oxo-1,4-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester (127720-04-1,67992-11-4) → 3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one (1380517-42-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 3 h

2: ethanol / Reflux

3: sodium hydroxide / 1 h / 100 °C

With hydrazine hydrate; sodium hydroxide; In ethanol;

DOI:10.1080/10426507.2011.643433

upstream raw materials:

2-aminopyridine

4-oxo-1,4-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester

4-oxo-1,4-dihydro-[1,8]-naphthyridine-3-carboxylic acid hydrazide

C₁₆H₁₃N₅O₂S

Downstream raw materials:

3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

C₂₄H₁₆ClN₇OS

2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid