2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid

Base Information

• Chemical Name: 2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid
• CAS No.: 1380517-46-3
• Molecular Formula: C₁₈H₁₃N₅O₃S
• Molecular Weight: 379.399
• Mol file: 1380517-46-3.mol

Synonyms:2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid

Chemical Property of 2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid

There total 6 articles about 2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one (1380517-42-9) + chloroacetic acid (79-11-8) → 2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid (1380517-46-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 2h;

DOI:10.1080/10426507.2011.643433

Reference yield:

4-oxo-1,4-dihydro-[1,8]-naphthyridine-3-carboxylic acid hydrazide (1268872-13-4) → 2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid (1380517-46-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / Reflux

2: sodium hydroxide / 1 h / 100 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C

With potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1080/10426507.2011.643433

Reference yield:

4-oxo-1,4-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester (127720-04-1,67992-11-4) → 2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid (1380517-46-3)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 3 h

2: ethanol / Reflux

3: sodium hydroxide / 1 h / 100 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C

With potassium carbonate; hydrazine hydrate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1080/10426507.2011.643433

upstream raw materials:

4-oxo-1,4-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester

4-oxo-1,4-dihydro-[1,8]-naphthyridine-3-carboxylic acid hydrazide

C₁₆H₁₃N₅O₂S

3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

Downstream raw materials:

3-(5-((1H-benzo[d]imidazol-2-yl)methylsulfonyl)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

C₂₄H₁₆ClN₇O₃S

C₂₄H₁₆ClN₇OS

3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one