3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

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Chemical Name:3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one
CAS No.:1380517-50-9
Molecular Formula:C₂₄H₁₇N₇OS
Molecular Weight:451.511
Hs Code.:

Synonyms:3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

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Chemical Property of 3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

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Technology Process of 3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

There total 8 articles about 3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1380517-46-3
2-((5-(1,4-dihydro-4-oxo-1,8-naphthyridin-3-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetic acid

: 95-54-5
1,2-diamino-benzene

: 1380517-50-9
3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

Guidance literature:: With hydrogenchloride; In water; at 100 ℃; for 4h;
DOI:10.1080/10426507.2011.643433

Reference yield:

: 4857-04-9
2-chloromethyl-1H-benzimidazole

: 1380517-42-9
3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

: 1380517-50-9
3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 2h; Temperature controlled oil-bath;
DOI:10.1080/10426507.2011.643433

Reference yield:

: 127720-04-1,67992-11-4
4-oxo-1,4-dihydro-[1,8]-naphthyridine-3-carboxylic acid ethyl ester

: 1380517-50-9
3-(5-((1H-benzo[d]imidazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazol-3-yl)-1,8-naphthyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 3 h

2: ethanol / Reflux

3: sodium hydroxide / 1 h / 100 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C / Temperature controlled oil-bath

With potassium carbonate; hydrazine hydrate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1080/10426507.2011.643433