? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal

Base Information

Chemical Name:? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal
CAS No.:1420791-01-0
Molecular Formula:C₁₆H₂₃F₃O₃Si
Molecular Weight:348.438
Hs Code.:

Synonyms:? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal

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Chemical Property of ? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal

Chemical Property:

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Technology Process of ? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal

There total 7 articles about ? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1420790-98-2
(S)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propan-1-ol

: 1420791-01-0
? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.tet.2012.11.087

Reference yield:

: 98-17-9
3-Trifluoromethylphenol

: 1420791-01-0
? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 1.5 h / 90 - 100 °C

2: hydrogenchloride; water / acetone / 1 h / 70 °C

3: pyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

5: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 - -20 °C / Inert atmosphere

6: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; di-isopropyl azodicarboxylate; water; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; acetone; toluene; 1: |Mitsunobu Displacement / 6: |Dess-Martin Oxidation;
DOI:10.1016/j.tet.2012.11.087

Reference yield:

: 1420790-91-5
(R)-(-)-2-hydroxy-3-(3-trifluoromethylphenoxy)propyl pivalate

: 1420791-01-0
? (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propanal

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 - -20 °C / Inert atmosphere

3: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

With 1H-imidazole; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; N,N-dimethyl-formamide; toluene; 3: |Dess-Martin Oxidation;
DOI:10.1016/j.tet.2012.11.087