(R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate

Base Information

Chemical Name:(R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate
CAS No.:1420790-95-9
Molecular Formula:C₂₁H₃₃F₃O₄Si
Molecular Weight:434.571
Hs Code.:

Synonyms:(R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate

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Chemical Property of (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate

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Technology Process of (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate

There total 6 articles about (R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

: 1420790-95-9
(R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h; Inert atmosphere;

Reference yield: 91.0%

: 1420790-91-5
(R)-(-)-2-hydroxy-3-(3-trifluoromethylphenoxy)propyl pivalate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1420790-95-9
(R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.tet.2012.11.087

Reference yield:

: (R)-(-)-2,2-dimethyl-4-(3-trifluoromethylphenoxy)methyl-1,3-dioxolane

: 1420790-95-9
(R)-(+)-2-(tert-butyldimethylsilyloxy)-3-(3-trifluoromethylphenoxy)propyl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / acetone / 1 h / 70 °C

2: pyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 0 - 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; hydrogenchloride; water; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2012.11.087