(4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone

Base Information

• Chemical Name: (4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone
• CAS No.: 763110-72-1
• Molecular Formula: C₅₃H₅₀Br₄O₂Si
• Molecular Weight: 1066.68

Synonyms:(4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone

Chemical Property of (4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone

There total 6 articles about (4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(3,5-diiodophenyl)-1-(trimethylsilyl)acetylene (210905-25-2) + (4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone (763110-69-6) → (4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone (763110-72-1)

Guidance literature:

With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; In triethylamine;

DOI:10.1002/ejoc.200400123

Reference yield:

4-t-butyl-2,6-dimethylbromobenzene (5345-05-1) → (4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone (763110-72-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium ribbon; iodine / diethyl ether / Heating

1.2: 36 percent / tetrahydrofuran; diethyl ether / 5 h / Heating

2.1: 71 percent / chromium(IV) oxide; cc. sulfuric acid / H₂O; acetone / 3 h

3.1: 56 percent / copper(I) iodide / bis(triphenylphosphane)palladium dichloride / triethylamine

4.1: 98 percent / aq. NaOH / 2-methyl-propan-2-ol / 20 °C

5.1: 88 percent / copper(I) iodide / bis(triphenylphosphane)palladium dichloride / triethylamine

With sodium hydroxide; copper(l) iodide; chromium (VI) oxide; sulfuric acid; iodine; magnesium; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; water; triethylamine; acetone; tert-butyl alcohol; 3.1: Sonogashira coupling reaction / 5.1: Sonogashira coupling reaction;

DOI:10.1002/ejoc.200400123

Reference yield:

2,4,6-tribromobenzaldehyde (45859-98-1) → (4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-trimethylsilanylethynyl-phenylethynyl}-phenyl)-methanone (763110-72-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium ribbon; iodine / diethyl ether / Heating

1.2: 36 percent / tetrahydrofuran; diethyl ether / 5 h / Heating

2.1: 71 percent / chromium(IV) oxide; cc. sulfuric acid / H₂O; acetone / 3 h

3.1: 56 percent / copper(I) iodide / bis(triphenylphosphane)palladium dichloride / triethylamine

4.1: 98 percent / aq. NaOH / 2-methyl-propan-2-ol / 20 °C

5.1: 88 percent / copper(I) iodide / bis(triphenylphosphane)palladium dichloride / triethylamine

With sodium hydroxide; copper(l) iodide; chromium (VI) oxide; sulfuric acid; iodine; magnesium; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; water; triethylamine; acetone; tert-butyl alcohol; 3.1: Sonogashira coupling reaction / 5.1: Sonogashira coupling reaction;

DOI:10.1002/ejoc.200400123

upstream raw materials:

2-(3,5-diiodophenyl)-1-(trimethylsilyl)acetylene

(4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone

4-t-butyl-2,6-dimethylbromobenzene

2,4,6-tribromobenzaldehyde

Downstream raw materials:

(4-tert-butyl-2,6-dimethyl-phenyl)-(2,6-dibromo-4-{3-[3,5-dibromo-4-(4-tert-butyl-2,6-dimethyl-benzoyl)-phenylethynyl]-5-ethynyl-phenylethynyl}-phenyl)-methanone

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