(S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate
CAS No.:1392489-31-4
Molecular Formula:C₃₁H₄₃F₂N₃O₆
Molecular Weight:591.696
Hs Code.:

Synonyms:(S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate

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Chemical Property of (S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate

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Technology Process of (S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate

There total 7 articles about (S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.8%

: 24424-99-5
di-tert-butyl dicarbonate

: 1354968-59-4
4-(2-Aminoethoxy)-benzamide hydrochloride

: 1392489-30-3
(S)-4,4-difluoro-1-(3-(4-(oxiran-2-ylmethoxy)phenyl)propyl)piperidine

: 1392489-31-4
(S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate

Guidance literature:: 4-(2-Aminoethoxy)-benzamide hydrochloride; (S)-4,4-difluoro-1-(3-(4-(oxiran-2-ylmethoxy)phenyl)propyl)piperidine; With potassium carbonate; In 1,1,1,3',3',3'-hexafluoro-propanol; water; at 90 ℃; for 1h; Microwave irradiation;

di-tert-butyl dicarbonate; In dichloromethane; 1,1,1,3',3',3'-hexafluoro-propanol; at 20 ℃; for 48h;

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 1392489-31-4
(S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / Reflux

2.1: tetrahydrofuran / 50 °C

3.1: triethylamine / 1,2-dichloro-ethane / -5 - 20 °C

4.1: potassium carbonate / ethanol / 40 - 50 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 20 °C

7.1: potassium carbonate / 1,1,1,3',3',3'-hexafluoro-propanol; water / 1 h / 90 °C / Microwave irradiation

7.2: 48 h / 20 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; 1,1,1,3',3',3'-hexafluoro-propanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 58608-97-2
3-(4-benzyloxyphenyl)propionic acid benzyl ester

: 1392489-31-4
(S)-tert-butyl-2-(4-carbamoylphenoxy)ethyl(3-(4-(3-(4,4-difluoropiperidin-1-yl)propyl)phenoxy)-2-hydroxypropyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 50 °C

2.1: triethylamine / 1,2-dichloro-ethane / -5 - 20 °C

3.1: potassium carbonate / ethanol / 40 - 50 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C

6.1: potassium carbonate / 1,1,1,3',3',3'-hexafluoro-propanol; water / 1 h / 90 °C / Microwave irradiation

6.2: 48 h / 20 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; 1,1,1,3',3',3'-hexafluoro-propanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;