N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide

Base Information

Chemical Name:N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide
CAS No.:1352836-08-8
Molecular Formula:C₂₉H₃₂FN₅O₂
Molecular Weight:501.604
Hs Code.:

Synonyms:N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide

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Chemical Property of N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide

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Technology Process of N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide

There total 6 articles about N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1352836-06-6
4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide

: 1352836-08-8
N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide

Guidance literature:: With hydrogen; Raney Ni; In methanol; for 3h; under 2844.39 Torr;

Reference yield:

: 5318-27-4
6-amino-1H-indole

: 1352836-08-8
N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tert-butyl alcohol / 84 h / 100 °C / Sealed tube

2: ytterbium(III) triflate / acetonitrile / 20 h / 50 °C

3: hydrogen / Raney Ni / methanol / 3 h / 2844.39 Torr

With hydrogen; sodium carbonate; ytterbium(III) triflate; In methanol; acetonitrile; tert-butyl alcohol;

Reference yield:

: 245117-18-4
4-(1H-indol-6-yl)morpholine

: 1352836-08-8
N-(3-(2-amino-1-(6-morpholino-1H-indol-3-yl)ethyl)-2-fluorophenyl)-4-(dimethylamino)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: ytterbium(III) triflate / acetonitrile / 20 h / 50 °C

2: hydrogen / Raney Ni / methanol / 3 h / 2844.39 Torr

With hydrogen; ytterbium(III) triflate; In methanol; acetonitrile;