4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide

Base Information

Chemical Name:4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide
CAS No.:1352836-06-6
Molecular Formula:C₂₉H₃₀FN₅O₄
Molecular Weight:531.587
Hs Code.:

Synonyms:4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide

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Chemical Property of 4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide

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Technology Process of 4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide

There total 4 articles about 4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

: 245117-18-4
4-(1H-indol-6-yl)morpholine

: 1352836-04-4
(E)-4-(dimethylamino)-N-(2-fluoro-3-(2-nitrovinyl)phenyl)benzamide

: 1352836-06-6
4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide

Guidance literature:: ytterbium(III) triflate; In acetonitrile; at 50 ℃; for 20h;

Reference yield:

: 5318-27-4
6-amino-1H-indole

: 1352836-06-6
4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tert-butyl alcohol / 84 h / 100 °C / Sealed tube

2: ytterbium(III) triflate / acetonitrile / 20 h / 50 °C

With sodium carbonate; ytterbium(III) triflate; In acetonitrile; tert-butyl alcohol;

Reference yield:

: 4755-50-4
4-(dimethylamino)benzoyl chloride

: 1352836-06-6
4-(dimethylamino)-N-(2-fluoro-3-(1-(6-morpholino-1H-indol-3-yl)-2-nitroethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 1,2-dichloro-ethane / 5 h / 70 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 5.33 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 2 h / 100 °C

3.2: pH 9

4.1: ytterbium(III) triflate / acetonitrile / 20 h / 50 °C

With pyridine; ammonium acetate; diisobutylaluminium hydride; acetic acid; ytterbium(III) triflate; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile;