(5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine

Base Information

• Chemical Name: (5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine
• CAS No.: 1228504-16-2
• Molecular Formula: C₁₈H₁₉IN₄O
• Molecular Weight: 434.28

Synonyms:(5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine

Chemical Property of (5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine

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Technology Process of (5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine

There total 1 articles about (5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminotetrahydropyran (38041-19-9) + 4-chloro-5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidine (1228504-15-1) → (5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine (1228504-16-2)

Guidance literature:

With sodium acetate; In ethanol; at 150 ℃; for 2h; Microwave irradiation;

Reference yield:

(5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine (1228504-16-2) + 4-trifluoromethylphenylboronic acid (128796-39-4) → (tetrahydro-pyran-4-yl)-[7-m-tolyl-5-(4-trifluoromethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine (1228503-10-3)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 95 ℃;

Reference yield:

1-Pentyne (627-19-0) + (5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine (1228504-16-2) → (5-pent-1-ynyl-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine (1228502-71-3)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 55 ℃;

upstream raw materials:

4-aminotetrahydropyran

4-chloro-5-iodo-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

(5-pent-1-ynyl-7-m-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(tetrahydro-pyran-4-yl)-amine

(tetrahydro-pyran-4-yl)-[7-m-tolyl-5-(4-trifluoromethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine

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