2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester

Base Information

• Chemical Name: 2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester
• CAS No.: 74514-70-8
• Molecular Formula: C₃₀H₃₄ClNO₄S
• Molecular Weight: 540.123
• Mol file: 74514-70-8.mol

Synonyms:2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester

Chemical Property of 2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester

There total 4 articles about 2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-allylglycine (1069-48-3,7685-44-1) → 2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester (74514-70-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 85.4 percent / triethylamine / H₂O; dioxane / 3.8 h / Ambient temperature

2: 80 percent / acetonitrile / 1 h / Ambient temperature

3: CH₂Cl₂ / 0.33 h / Ambient temperature

With triethylamine; In 1,4-dioxane; dichloromethane; water; acetonitrile;

DOI:10.1021/ja00532a042

Reference yield:

2-((tert-butyloxycarbonyl)amino)-4-pentenoic acid (119479-32-2) → 2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester (74514-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetonitrile / 1 h / Ambient temperature

2: CH₂Cl₂ / 0.33 h / Ambient temperature

In dichloromethane; acetonitrile;

DOI:10.1021/ja00532a042

Reference yield:

diazodiphenylmethane (908093-98-1) → 2-tert-Butoxycarbonylamino-4-chloro-5-p-tolylsulfanyl-pentanoic acid benzhydryl ester (74514-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / acetonitrile / 1 h / Ambient temperature

2: CH₂Cl₂ / 0.33 h / Ambient temperature

In dichloromethane; acetonitrile;

DOI:10.1021/ja00532a042

upstream raw materials:

p-methylbenzenesulfenyl chloride

diphenylmethyl (N-t-butoxycarbonyl)-2-aminopent-4-enoate

rac-allylglycine

2-((tert-butyloxycarbonyl)amino)-4-pentenoic acid

Downstream raw materials:

2-amino-4-chloro-5-(p-tolylsulfinyl)pentanoic acid trifluoroacetyl salt

2-tert-Butoxycarbonylamino-4-chloro-5-(toluene-4-sulfinyl)-pentanoic acid benzhydryl ester