119479-32-2

Basic information

• Product Name: 2-(Tert-Butoxycarbonylamino)Pent-4-Enoic Acid
• Synonyms: 2-(Tert-Butoxycarbonylamino)Pent-4-Enoic Acid;2-Boc-AMino-4-pentenoic acid;Boc-DL-Allylglycine
• CAS NO: 119479-32-2
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.25
• Mol File: 119479-32-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 109 °C(Solv: dichloromethane (75-09-2); pentane (109-66-0))
• Boiling Point: 352.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.097±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.83±0.10(Predicted)
• CAS DataBase Reference: 2-(Tert-Butoxycarbonylamino)Pent-4-Enoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Tert-Butoxycarbonylamino)Pent-4-Enoic Acid(119479-32-2)
• EPA Substance Registry System: 2-(Tert-Butoxycarbonylamino)Pent-4-Enoic Acid(119479-32-2)

Safety Data

• Hazardous Substances Data: 119479-32-2(Hazardous Substances Data)

Usage

General Description

2-(Tert-Butoxycarbonylamino)Pent-4-Enoic Acid is a chemical compound with the formula C10H17NO4. It is a derivative of pent-4-enoic acid that has a tert-butoxycarbonylamino group attached to the carbon chain. 2-(Tert-Butoxycarbonylamino)Pent-4-Enoic Acid is used in organic synthesis and pharmaceutical research as a building block for the preparation of various compounds. As a tert-butoxycarbonylamino derivative, it can be used as a protecting group for the amino function in peptide synthesis, allowing for selective modification of the molecule. Its applications also extend to the field of medicinal chemistry, where it can be used to develop new drug candidates with potential therapeutic properties.

Upstream product

• 1069-48-3 rac-allylglycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 68843-72-1 ethyl 2-aminopent-4-enoate 
• 106928-50-1 methyl 2-[(tert-butoxycarbonyl)amino]pent-4-enoate 
• 31954-27-5 N-(tert-butoxycarbonyl)glycine methyl ester 
• 124373-83-7 allyl 2-(tert-butoxycarbonylamino)acetate 
• 4530-20-5 BOC-glycine 
• 3182-77-2 N-allylglycine 
• 115289-57-1 ethyl N-(diphenylmethylene)-2-amino-4-pentenoate 
• 135722-56-4 ethyl (RS)-N-(tert-butoxycarbonyl)-2-aminopent-4-enoate 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 106-95-6 allyl bromide 
• 1538-75-6 2,2-dimethylpropanoic anhydride 

Downstream Products

• 74514-73-1 diphenylmethyl (N-t-butoxycarbonyl)-2-aminopent-4-enoate 
• 959408-01-6 Boc-allylglycine-N-(2,4-dimethoxybenzyl)allylglycine methyl ester 
• 957208-96-7 C₂₉H₃₂N₂O₄ 
• 274918-46-6 tert-butyl (1-oxopent-4-en-2-yl)carbamate 
• 876624-56-5 1-(2-tert-butoxycarbonylamino-pent-4-enoyl)-5-vinyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 50299-15-5 methyl (S)-allylglycinate 
• 796072-02-1 2-tert-butoxycarbonylamino-5-(4'-dibenzofuran-4-yl-biphen-4-yl)-5-pentanoic acid 
• 796072-32-7 2-tert-butoxycarbonylamino-5-(4'-dibenzofuran-4-yl-biphen-4-yl)-5-pentanoic acid methyl ester 
• 796072-01-0 2-tert-butoxycarbonylamino-5-(4'-dibenzofuran-4-yl-biphen-4-yl)-4-pentenoic acid 
• 796072-31-6 2-tert-butoxycarbonylamino-5-(4'-dibenzofuran-4-yl-biphen-4-yl)-5-pentenoic acid methyl ester 
• 1196038-87-5 [1-carbamoyl-4-(4-methoxy-phenyl)-butyl]-carbamic acid tert-butyl ester 
• 1196038-88-6 [1-aminomethyl-4-(4-methoxy-phenyl)-butyl]-carbamic acid tert-butyl ester 
• 894401-46-8 2-tert-butoxycarbonylamino-5-[4-(methyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester 
• 89985-87-5 methyl (2S)-2-tert-butoxycarbonylamino-4-pentenoate 

Relevant articles and documents

Modified N-acyl-homoserine lactones as chemical probes for the elucidation of plant-microbe interactions

Gram-negative bacteria often use N-acyl-homoserine lactones (AHLs) as signal molecules to monitor their local population densities and to regulate gene-expression in a process called "Quorum Sensing" (QS). This cell-to-cell communication allows bacteria to adapt to environmental changes and to behave as multicellular communities. QS plays a key role in both bacterial virulence towards the host and symbiotic interactions with other organisms. Plants also perceive AHLs and respond to them with changes in gene expression or modifications in development. Herein, we report the synthesis of new AHL-derivatives for the investigation and identification of AHL-interacting proteins. We show that our new compounds are still recognised by different bacteria and that a novel biotin-tagged-AHL derivative interacts with a bacterial AHL receptor.

Amino [13]-macrodilactones: Synthesis, derivatization, and structural motifs

Macrocycles draw their usefulness from an ability to balance size, shape, and functionality according to general principles. These structural parameters manifest as the conformations of macrocycles and ultimately their functions. Reported here are results of an investigation on [13]-macrodilactones that take up unique folded conformations based on the interplay of multi-atom planar units and sterics. The defining feature of this group of [13]-macrodilactones is the pendant amine group attached to the ring. Amidation of the ring generated analogs that were designed to imitate features of the macrocyclic natural product Teixobactin. We also show that intramolecular interactions, and the A-value of an acylated amine can explain the conformational preferences in macrocycles.

THERAPEUTIC OR PROPHYLACTIC AGENT FOR LEUKEMIA

A therapeutic or prophylactic agent for leukemia is disclosed. The therapeutic or prophylactic agent comprises as an effective ingredient a glycine derivative having a specific structure or a pharmaceutically acceptable salt thereof, for example, the below-described compound [(E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]. The therapeutic or prophylactic agent for leukemia according to the present invention shows the excellent absorbability and in vivo stability when orally administered, and exhibits prominent therapeutic or prophylactic effects.