2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]

Base Information

Chemical Name:2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]
CAS No.:1431533-58-2
Molecular Formula:C₁₉H₂₀FNO₄
Molecular Weight:345.371
Hs Code.:

Synonyms:2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]

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Chemical Property of 2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]

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Technology Process of 2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]

There total 6 articles about 2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methoxycarbonylsulfamoyl-triethylammmonium hydroxide

: 1431533-56-0
4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide

: 1431533-58-2
2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]

Guidance literature:: 4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide; With sulfur trioxide pyridine complex; triethylamine; In dimethyl sulfoxide; for 1h; Inert atmosphere;

methoxycarbonylsulfamoyl-triethylammmonium hydroxide; In tetrahydrofuran; at 60 ℃; for 1h;

Reference yield:

: 350-29-8
3-fluoro-4-hydroxybenzoic acid

: 1431533-58-2
2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / methanol / 24 h / Reflux

1.2: 1 h / 70 °C

1.3: 2 h / 50 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere

3.2: 1 h / 60 °C

With oxalyl dichloride; sulfuric acid; sulfur trioxide pyridine complex; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dimethyl sulfoxide;

Reference yield:

: 1021144-38-6
4-(cyclopropylmethoxy)-3-fluorobenzoic acid

: 1431533-58-2
2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1 h / Inert atmosphere

2.2: 1 h / 60 °C

With oxalyl dichloride; sulfur trioxide pyridine complex; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dimethyl sulfoxide;