4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide

Base Information

Chemical Name:4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide
CAS No.:1431533-56-0
Molecular Formula:C₁₉H₂₄FNO₅
Molecular Weight:365.402
Hs Code.:

Synonyms:4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide

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Chemical Property of 4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide

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Technology Process of 4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide

There total 4 articles about 4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-amino-1,4-dioxaspiro[4.5]decan-8-ol

: 1021144-38-6
4-(cyclopropylmethoxy)-3-fluorobenzoic acid

: 1431533-56-0
4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide

Guidance literature:: 4-(cyclopropylmethoxy)-3-fluorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 0.5h;

7-amino-1,4-dioxaspiro[4.5]decan-8-ol; In tetrahydrofuran; methanol;

Reference yield:

: 350-29-8
3-fluoro-4-hydroxybenzoic acid

: 1431533-56-0
4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / methanol / 24 h / Reflux

1.2: 1 h / 70 °C

1.3: 2 h / 50 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

With oxalyl dichloride; sulfuric acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol;

Reference yield:

: 34989-52-1
(+/-)-spiro[1,3-dioxolane-2,3'-[7]oxabicyclo[4.1.0]heptane]

: 1431533-56-0
4-(cyclopropylmethoxy)-3-fluoro-N-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 90 °C

2: hydrogen; palladium 10% on activated carbon / water; ethanol / 2 h / 20 °C / 3800.26 Torr

3: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

With oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; water; isopropyl alcohol;