5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Base Information

Chemical Name:5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole
CAS No.:1431533-62-8
Molecular Formula:C₂₀H₂₃FN₄O₃
Molecular Weight:386.426
Hs Code.:

Synonyms:5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

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Chemical Property of 5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Chemical Property:

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Technology Process of 5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

There total 10 articles about 5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: sodium azide

: 1431533-61-7
1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-5-yl)oxy)propan-2-ol

: 124-63-0
methanesulfonyl chloride

: 1431533-62-8
5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Guidance literature:: 1-((2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-5-yl)oxy)propan-2-ol; methanesulfonyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

sodium azide; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 1431533-58-2
2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-6,7-dihydro-4H-spiro[1,3-benzoxazole-5,2'-[1,3]dioxolane]

: 1431533-62-8
5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol; tetrahydrofuran; water / 1 h / 70 °C

1.2: 0.33 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere

3.1: tetrahydrofuran / 0.17 h / 20 °C

3.2: 0.17 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

4.2: 2 h / 100 °C

With hydrogenchloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; methanol; water;

Reference yield:

: 1431533-59-3
2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-5-ol

: 1431533-62-8
5-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / Inert atmosphere

2.1: tetrahydrofuran / 0.17 h / 20 °C

2.2: 0.17 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.17 h / 20 °C

3.2: 2 h / 100 °C

With potassium tert-butylate; triethylamine; In tetrahydrofuran;