(4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:(4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole
CAS No.:126428-98-6
Molecular Formula:C₁₇H₁₆FNOS
Molecular Weight:301.385
Hs Code.:

Synonyms:(4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

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Technology Process of (4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

There total 2 articles about (4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96795-24-3
D-(-)-threo-2-phenyl-4-(4-(methylthio)phenyl)-2-oxazole-5-methanol

: 126428-98-6
(4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: D-(-)-threo-2-phenyl-4-(4-(methylthio)phenyl)-2-oxazole-5-methanol; With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -78 - 20 ℃; for 72h;

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; pH=5 - 6;

Reference yield:

: (2S,3R)-3-(4-methyl-thiophenyl)-3-hydroxy-2-amino-1-fluoro-propane

: 98-88-4
benzoyl chloride

: 124-63-0
methanesulfonyl chloride

: 126428-98-6
(4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: With sodium hydrogencarbonate; sodium carbonate; triethylamine; In dichloromethane;

Reference yield:

: 126428-98-6
(4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

: 859520-25-5
(4S,5R)-4-(fluoromethyl)-5-[4-(methylsulfinyl)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole

Guidance literature:: (4S,5R)-4-(fluoromethyl)-5-[4-(methylthio)phenyl]-2-phenyl-4,5-dihydro-1,3-oxazole; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -30 - -20 ℃; for 5h;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; Product distribution / selectivity;