1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole

Base Information

• Chemical Name: 1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole
• CAS No.: 114973-96-5
• Molecular Formula: C₁₇H₁₇N₃O₂
• Molecular Weight: 295.341
• Mol file: 114973-96-5.mol

Synonyms:1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole

Chemical Property of 1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole

There total 4 articles about 1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

conc. ammonia water + 2-methoxy-4-methylbenzaldehyde (57415-35-7) + 1-hydroxyimino-1-(pyridin-3-yl)acetone → 1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole (114973-96-5)

Guidance literature:

In 1,4-dioxane; ethanol; chloroform; di-isopropyl ether;

Reference yield:

1-(pyridin-3-yl)-2-propanone (6302-03-0) → 1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole (114973-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 58.5 percent / aq. HCl, isoamyl nitrite / tetrahydrofuran / 18 h / Ambient temperature

2: ammonium acetate, acetic acid / 4 h / Heating

With ammonium acetate; hydrogenchloride; acetic acid; isopentyl nitrite; In tetrahydrofuran;

DOI:10.1248/cpb.40.3206

Reference yield:

3-pyridineacetic acid hydrochloride (6419-36-9) → 1-hydroxy-2-(2-methoxy-4-methylphenyl)-4-methyl-5-(pyridin-3-yl)imidazole (114973-96-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 39.3 g / sodium acetate / 11 h / 75 - 80 °C

2: 58.5 percent / aq. HCl, isoamyl nitrite / tetrahydrofuran / 18 h / Ambient temperature

3: ammonium acetate, acetic acid / 4 h / Heating

With ammonium acetate; hydrogenchloride; sodium acetate; acetic acid; isopentyl nitrite; In tetrahydrofuran;

DOI:10.1248/cpb.40.3206

upstream raw materials:

1-hydroxyimino-1-(3-pyridyl)-2-propanone

2-methoxy-4-methylbenzaldehyde

1-(pyridin-3-yl)-2-propanone

3-pyridineacetic acid hydrochloride