5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide

Base Information

Chemical Name:5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide
CAS No.:1056635-79-0
Molecular Formula:C₂₈H₃₄N₈O₄S
Molecular Weight:578.695
Hs Code.:

Synonyms:5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide

Suppliers and Price of 5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide

There total 4 articles about 5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1056635-95-0
5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

: 108-00-9
N,N-dimethylethylenediamine

: 1056635-79-0
5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide

Guidance literature:: 5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid; With HATU; In N,N-dimethyl-formamide; for 0.0833333h; Sonication;

N,N-dimethylethylenediamine; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 380430-57-9
4-(methylsulfonylamino)phenyl boronic acid

: 1056635-79-0
5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / propan-1-ol; water; toluene / 66 h / 100 °C

2.1: potassium carbonate / acetone

2.2: 48 h / 20 °C

3.1: toluene-4-sulfonic acid / 1,4-dioxane / 100 °C

4.1: HATU / N,N-dimethyl-formamide / 0.08 h / Sonication

4.2: 20 °C

With sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; propan-1-ol; water; N,N-dimethyl-formamide; acetone; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1056636-13-5
N-(4-(2-chloropyrimidin-4-yl)phenyl)methanesulfonamide

: 1056635-79-0
5-(4-(4-(n-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-N-(2-(dimethylamino)ethyl)-2-morpholinobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone

1.2: 48 h / 20 °C

2.1: toluene-4-sulfonic acid / 1,4-dioxane / 100 °C

3.1: HATU / N,N-dimethyl-formamide / 0.08 h / Sonication

3.2: 20 °C

With potassium carbonate; toluene-4-sulfonic acid; HATU; In 1,4-dioxane; N,N-dimethyl-formamide; acetone;