5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

Base Information

Chemical Name:5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid
CAS No.:1056635-95-0
Molecular Formula:C₂₄H₂₄N₆O₅S
Molecular Weight:508.558
Hs Code.:

Synonyms:5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

Suppliers and Price of 5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

There total 3 articles about 5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1056636-14-6
N-(4-(2-chloropyrimidin-4-yl)phenyl)-N-(cyanomethyl)methanesulfonamide

: 65989-45-9
5-amino-2-morpholin-4-yl-benzoic acid

: 1056635-95-0
5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃;

Reference yield:

: 380430-57-9
4-(methylsulfonylamino)phenyl boronic acid

: 1056635-95-0
5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / propan-1-ol; water; toluene / 66 h / 100 °C

2.1: potassium carbonate / acetone

2.2: 48 h / 20 °C

3.1: toluene-4-sulfonic acid / 1,4-dioxane / 100 °C

With sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; propan-1-ol; water; acetone; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1056636-13-5
N-(4-(2-chloropyrimidin-4-yl)phenyl)methanesulfonamide

: 1056635-95-0
5-(4-(4-(N-(cyanomethyl)methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone

1.2: 48 h / 20 °C

2.1: toluene-4-sulfonic acid / 1,4-dioxane / 100 °C

With potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; acetone;