diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate

Base Information

• Chemical Name: diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate
• CAS No.: 1030320-79-6
• Molecular Formula: C₂₃H₂₃IO₄
• Molecular Weight: 490.338
• Mol file: 1030320-79-6.mol

Synonyms:diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate

Chemical Property of diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate

There total 2 articles about diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

diethyl (2-iodobenzyl)malonate (111373-31-0) + 1-bromo-3-phenylprop-2-yne (1794-48-5) → diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate (1030320-79-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200701043

Reference yield: 75.0%

2-(3-phenylprop-2-ynyl)malonic acid diethyl ester (93006-71-4) + 2-Iodobenzyl bromide (40400-13-3) → diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate (1030320-79-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201612127

Reference yield: 95.0%

diethyl 2-(2-iodobenzyl)-2-(3-phenylprop-2-yn-1-yl)malonate (1030320-79-6) + N,N'-di-tert-butyldiaziridinone (19656-74-7) → diethyl 1-(tert-butyl)-2-phenyl-1,5-dihydrobenzo[cd]indole-4,4(3H)-dicarboxylate

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 130 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01365

upstream raw materials:

diethyl (2-iodobenzyl)malonate

1-bromo-3-phenylprop-2-yne

2-(3-phenylprop-2-ynyl)malonic acid diethyl ester

2-Iodobenzyl bromide

Downstream raw materials:

diethyl (4Z)-4-(3-cyclohexenyl-1-phenylprop-2-ynylidene)-1,2,3,4-tetrahydronaphthalene-2,2-dicarboxylate

diethyl (Z)-4-[phenyl(o-tolyl)methylene]-1,2,3,4-tetrahydronaphthalene-2,2-dicarboxylate

diethyl (Z)-4-[phenyl(m-tolyl)methylene]-1,2,3,4-tetrahydronaphthalene-2,2-dicarboxylate

diethyl (Z)-4-[phenyl(p-tolyl)methylene]-1,2,3,4-tetrahydronaphthalene-2,2-dicarboxylate