Phenol, 2,4-Dichlor-5-hydrazin-, Monohydrochlorid

Base Information

• Chemical Name: Phenol, 2,4-Dichlor-5-hydrazin-, Monohydrochlorid
• CAS No.: 189573-21-5
• Molecular Formula: C₆H₆Cl₂N₂O*ClH
• Molecular Weight: 229.493
• Mol file: 189573-21-5.mol

Synonyms:Phenol,2,4-dichloro-5-hydrazino-, monohydrochloride (9CI)

Chemical Property of Phenol, 2,4-Dichlor-5-hydrazin-, Monohydrochlorid

Chemical Property:

• PSA: 58.28000
• LogP: 3.55990

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 2,4-Dichlor-5-hydrazin-, Monohydrochlorid

There total 5 articles about Phenol, 2,4-Dichlor-5-hydrazin-, Monohydrochlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.8%

→ (2,4-dichloro-5-hydroxy)phenylhydrazine hydrochloride (189573-21-5)

Guidance literature:

Reference yield: 41.0%

→ (2,4-dichloro-5-hydroxy)phenylhydrazine hydrochloride (189573-21-5) + 2,4-dichloro-5-hydroxyphenylhydrazine (39807-21-1)

Guidance literature:

Reference yield:

N-(2,4-dichloro-5-hydroxyphenyl)acetamide (67669-19-6) → (2,4-dichloro-5-hydroxy)phenylhydrazine hydrochloride (189573-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol; water / 2 h / 75 °C / Inert atmosphere

2.1: sodium nitrite / water / 1.25 h / 0 - 5 °C / Inert atmosphere

2.2: 1 h / 0 - 65 °C

2.3: 1 h / 40 - 50 °C

With hydrogenchloride; sodium nitrite; In methanol; water;

DOI:10.1021/op9901994

upstream raw materials:

N-(2,4-dichloro-5-hydroxyphenyl)acetamide

m-Hydroxyaniline

4,6-dichloro-1-hydroxy-3-aminobenzene

Downstream raw materials:

2-(2,4-dichloro-5-hydroxyphenyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-A]pyridin-3(2H)-one

azafenidin

Refernces

• 1、 -. "Process for preparing arylhydrazines". . . Retrieved 2008/06/13.