67669-19-6

Basic information

• Product Name: N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE
• Synonyms: N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE;2',4'-DICHLORO-5'-HYDROXYACETANILIDE;2,4-DICHLORO-5-HYDROXYACETANILIDE;5-ACETYLAMINO-2,4-DICHLOROPHENOL
• CAS NO: 67669-19-6
• Molecular Formula: C₈H₇Cl₂NO₂
• Molecular Weight: 220.05
• EINECS: 429-110-0
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 67669-19-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 233-236 °C
• Boiling Point: 394.5 °C at 760 mmHg
• Flash Point: 192.4 °C
• Appearance: White to tan powder, crystals or crystalline powder and/or chunks
• Density: 1.519 g/cm³
• Vapor Pressure: 8.67E-07mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE(67669-19-6)
• EPA Substance Registry System: N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE(67669-19-6)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 26-36-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 67669-19-6(Hazardous Substances Data)

Usage

General Description

N-(2,4-Dichloro-5-hydroxyphenyl)acetamide is a chemical compound with the molecular formula C8H8Cl2NO2. It is an amide derivative of 2,4-dichloro-5-hydroxyphenylacetic acid, which is a metabolite of an herbicide called 2,4-D. N-(2,4-Dichloro-5-hydroxyphenyl)acetamide is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential as an anti-inflammatory and analgesic agent, showing some promising effects in animal models. However, its exact mechanisms of action and potential side effects in humans are still under investigation.

InChI:InChI=1/C8H7Cl2NO2/c1-4(12)11-7-3-8(13)6(10)2-5(7)9/h2-3,13H,1H3,(H,11,12)

Upstream product

• 621-42-1 meta-hydroxyacetanilide 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 591-27-5 m-Hydroxyaniline 
• 631-61-8 ammonium acetate 

Downstream Products

• 39807-17-5 2,4-dichloro-5-(2-propynyloxy)aniline 
• 189573-21-5 (2,4-dichloro-5-hydroxy)phenylhydrazine hydrochloride 
• 68049-71-8 2-(2,4-dichloro-5-hydroxyphenyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-A]pyridin-3(2H)-one 
• 68049-83-2 azafenidin 
• 380843-75-4 bosutinib 
• 380844-49-5 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 
• 846023-24-3 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide 
• 65182-98-1 N-(2,4-dichloro-5-methoxybenzene)acetamide 
• 65948-71-2 N-[2,4-dichloro-5-(propan-2-yloxy)phenyl]acetamide 
• 98446-49-2 2,4-dichloro-5-methoxyaniline 
• 50375-04-7 1,3-dichloro-4,6-dimethoxybenzene 
• 380844-03-1 2,4-dichloro-5-propoxyaniline 
• 380844-01-9 2,4-dichloro-5-ethoxyaniline 
• 65948-72-3 5-n-Propoxy-2,4-dichloracetanilid 

Relevant articles and documents

Preparation method of mecitinib raw material (by machine translation)

The method comprises the following steps: preparing,methyl 3 -(-ethyl-)-amido phenol, dichloro - 5 5-methoxyaniline (by reaction with potassium chloride) sodium 2,4 - to generate (dichloro - 5 5-methan)-methaneth, 2,4 -amidobenzylether (in a chlorine substitution reaction). 2,4 - The method comprises the following steps: reacting m-methyl-methanethinonylphenol and hydrogen peroxide, to generate, dichloro - 5 5-methoxyaniline. The method comprises the following steps of reacting m-aminophenol as a raw material to synthesize methyl chloride 2,4 - potassium, and benzoyl (and reacting; with chloromethane in, a mixture) of, sodium, chloride and methyl chloride, and reacting with chloromethane in a reaction condition. (by machine translation)

A method for synthesizing intermediate oxadiazon

The invention discloses a method for synthesizing intermediate oxadiazon, comprises the following steps: takes amino phenol as an initial raw material; to m-aminophenol acylation reaction is carried out, thereby obtaining a reaction solution A; the reaction solution A to proceed chlorination reaction, to obtain 2, 4 - dichloro - 5 hydroxy acetanilide; to the 2, 4 - dichloro - 5 hydroxy acetanilide etherification reaction, to obtain 2, 4 - dichloro - 5 isopropoxy acetanilide; to the 2, 4 - dichloro - 5 isopropoxy acetyl aniline to deprotected, get 2, 4 - dichloro - 5 isopropoxyaniline. The invention of 2, 4 - dichloro - 5 - isopropoxy aniline synthesis method to avoid the pollution of the environment, but there are few process steps, high yield.

Discovery and development of a commercial synthesis of azafenidin

A commercial synthesis of the DuPont herbicide azafenidin is described. Discovery of a novel synthesis of the triazolinone ring system and a practical, environmentally benign process to 5-cyanovaleramide were critical breakthroughs in enabling azafenidin to be manufactured at an acceptable cost. The process began with the selective hydrolysis of DuPont's nylon intermediate, adiponitrile, to 5-cyanovaleramide. This was converted via Hofmann rearrangement and Pinner-type cyclization to afford the key amidine carboxylate intermediate containing both carbon atoms of the triazolinone ring. The preservation of all six carbon atoms of adiponitrile set up a 2 + 3 cyclocondensation with arylhydrazines, which replaced a costly 4 + 1 cyclocondensation of an amidrazone with phosgene or a phosgene surrogate used in the original route. This new triazolinone process was optimized to afford the commercial product in a highly efficient and economical fashion.