1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one

Base Information

Chemical Name:1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one
CAS No.:688745-55-3
Molecular Formula:C₁₄H₁₆BrNO₄
Molecular Weight:342.189
Hs Code.:

Synonyms:1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one

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Chemical Property of 1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one

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Technology Process of 1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one

There total 2 articles about 1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 15159-40-7
4-morpholinocarbonyl chloride

: 56609-15-5
3'-bromo-2'-hydroxy-5'-methylacetophenone

: 688745-55-3
1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one

Guidance literature:: 3'-bromo-2'-hydroxy-5'-methylacetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

4-morpholinocarbonyl chloride; In tetrahydrofuran; at 20 ℃;
DOI:10.1071/CH03113

Reference yield:

: 1450-72-2
5-methyl-2-hydroxyacetophenone

: 688745-55-3
1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 74 percent / Br₂ / CHCl₃ / 3 h / 0 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / 0 °C

2.2: 52 percent / tetrahydrofuran / 20 °C

With bromine; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform;
DOI:10.1071/CH03113

Reference yield:

: 688745-55-3
1-(3-bromo-2-hydroxy-5-methylphenyl)-3-morpholin-4-yl-3-oxopropan-1-one

: 6-methyl-2-morpholin-4-yl-8-phenyl-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: Tf₂O / CH₂Cl₂ / 20 °C

1.2: 25 percent / MeOH / 4 h / 20 °C

2.1: 30 percent / K₃PO₄ / dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium (II) / dioxane / 48 h / 85 °C

With potassium phosphate; trifluoromethylsulfonic anhydride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; 2.1: Suzuki coupling;
DOI:10.1071/CH03113