(4-bromobutoxy)(tert-butyl)diphenylsilane

Base Information

• Chemical Name: (4-bromobutoxy)(tert-butyl)diphenylsilane
• CAS No.: 125010-58-4
• Molecular Formula: C₂₀H₂₇BrOSi
• Molecular Weight: 391.423
• Mol file: 125010-58-4.mol

Synonyms:(4-bromobutoxy)(tert-butyl)diphenylsilane

Chemical Property of (4-bromobutoxy)(tert-butyl)diphenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-bromobutoxy)(tert-butyl)diphenylsilane

There total 2 articles about (4-bromobutoxy)(tert-butyl)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(tret-butyldiphenylsilyloxy)butan-1-ol (130372-07-5) → (4-bromobutoxy)(tert-butyl)diphenylsilane (125010-58-4)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201800792

Reference yield: 94.0%

4-Bromo-1-butanol (33036-62-3) + tert-butylchlorodiphenylsilane (58479-61-1) → (4-bromobutoxy)(tert-butyl)diphenylsilane (125010-58-4)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 9h;

DOI:10.1002/anie.201508405

Reference yield: 89.0%

2-(3-(1,3-dithian-2-yl)propoxy)tetrahydro-2H-pyran (139230-31-2) + (4-bromobutoxy)(tert-butyl)diphenylsilane (125010-58-4) → tert-butyldiphenyl(4-(2-(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)-1,3-dithian-2-yl)butoxy)silane (182008-77-1)

Guidance literature:

2-(3-(1,3-dithian-2-yl)propoxy)tetrahydro-2H-pyran; With n-butyllithium; In tetrahydrofuran; at -20 ℃; for 2h;

(4-bromobutoxy)(tert-butyl)diphenylsilane; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1002/anie.201508405

upstream raw materials:

4-Bromo-1-butanol

tert-butylchlorodiphenylsilane

4-(tret-butyldiphenylsilyloxy)butan-1-ol

Downstream raw materials:

7-(tert-butyldiphenylsilyloxy)-hept-2-yn-1-ol

tert-butyl(methoxy)diphenylsilane

t-butyl diphenylsilanol

1-bromo-7-tert-butyldiphenylsilyloxy-2-heptyne

Refernces

• 1、 Morozova, Varvara,Skotnitzki, Juri,Moriya, Kohei,Karaghiosoff, Konstantin,Knochel, Paul. "Preparation of Optically Enriched Secondary Alkyllithium and Alkylcopper Reagents—Synthesis of (?)-Lardolure and Siphonarienal". supporting information. p. 5516 - 5519. Retrieved 2018/04/02.
• 2、 Cravatt, Benjamin F.,Lerner, Richard A.,Boger, Dale L.. "Structure determination of an endogenous sleep-inducing lipid, cis-9-octadecenamide (oleamide): A synthetic approach to the chemical analysis of trace quantities of a natural product". . p. 580 - 590. Retrieved 2007/10/03.