(1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate

Base Information

Chemical Name:(1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate
CAS No.:1304668-86-7
Molecular Formula:C₂₂H₃₄O₄Si
Molecular Weight:390.595
Hs Code.:

Synonyms:(1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate

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Chemical Property of (1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate

Chemical Property:

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Technology Process of (1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate

There total 3 articles about (1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 219496-66-9
(1R,3S)-3-(benzyloxycarbonyl)-1,2,2-trimethylcyclopentanecarboxylic acid

: 1304668-86-7
(1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Reflux;
DOI:10.1016/j.tetlet.2011.01.028

Reference yield:

: 595-29-9
camphoric anhydride

: 1304668-86-7
(1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dichloromethane; mineral oil

1.2: 4 h / Reflux

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Reflux

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; mineral oil;
DOI:10.1016/j.tetlet.2011.01.028

Reference yield:

: 124-83-4
D-(+)-camphoric acid

: 1304668-86-7
(1R,3S)-3-benzyl 1-(2-(trimethylsilyl)ethyl) 1,2,2-trimethylcyclopentane-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / Reflux

2.1: sodium hydride / dichloromethane; mineral oil

2.2: 4 h / Reflux

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Reflux

With dmap; thionyl chloride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane; mineral oil;
DOI:10.1016/j.tetlet.2011.01.028