Technology Process of (1R,3S)-[2-(trimethylsilyl)ethyl] 3-((2-benzyloxyethyl)(propyl)amino)-1,2,2-trimethylcyclopentanecarboxylate
There total 6 articles about (1R,3S)-[2-(trimethylsilyl)ethyl] 3-((2-benzyloxyethyl)(propyl)amino)-1,2,2-trimethylcyclopentanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / dichloromethane; mineral oil
1.2: 4 h / Reflux
2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Reflux
3.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / 760.05 Torr
4.1: chloroformic acid ethyl ester; triethylamine / acetone / 0.67 h / 0 °C
4.2: 0.67 h / 0 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
5.2: 24 h / 20 °C
6.1: sodium cyanoborohydride; acetic acid / methanol / 24 h / pH 5.5 / Reflux
With
dmap; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; sodium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1016/j.tetlet.2011.01.028
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Reflux
2.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / 760.05 Torr
3.1: chloroformic acid ethyl ester; triethylamine / acetone / 0.67 h / 0 °C
3.2: 0.67 h / 0 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
4.2: 24 h / 20 °C
5.1: sodium cyanoborohydride; acetic acid / methanol / 24 h / pH 5.5 / Reflux
With
dmap; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; sodium cyanoborohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tetlet.2011.01.028
