9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Base Information

Chemical Name:9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine
CAS No.:306305-06-6
Molecular Formula:C₃₂H₃₉N₅O₃Si
Molecular Weight:569.779
Hs Code.:

Synonyms:9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Suppliers and Price of 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

There total 6 articles about 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34241-39-9
azobisisobutyronitrile

: 42908-73-6
4-fluorophenyl chlorothionoformate

: 306305-05-5
9-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

: 306305-06-6
9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Guidance literature:: With dmap; sodium chloride; In water; toluene; acetonitrile;

Reference yield:

: 1053714-14-9
thiocarbonic acid O-[2-(6-amino-purin-9-yl)-4-benzyloxy-5-benzyloxymethyl-5-triethylsilanylethynyl-tetrahydro-furan-3-yl] ester O-phenyl ester

: 306305-06-6
9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 85 ℃; for 1h;
DOI:10.1021/jm000209n

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 306305-06-6
9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 25.5 h / Heating

2: 86 percent / triethylamine; methanol / 24 h / 20 °C

3: 4-(dimethylamino)pyridine / acetonitrile / 1 h / 20 °C

4: 2,2'-azobis(isobutyronitrile); tri-n-butyltin hydride / toluene / 1 h / 85 °C

With methanol; dmap; N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tri-n-butyl-tin hydride; triethylamine; In 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jm000209n