9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

Base Information

Chemical Name:9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine
CAS No.:1054625-37-4
Molecular Formula:C₂₆H₂₅N₅O₃
Molecular Weight:455.516
Hs Code.:

Synonyms:9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

Suppliers and Price of 9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

There total 6 articles about 9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 306305-06-6
9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

: 1054625-37-4
9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jm000209n

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 1054625-37-4
9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 25.5 h / Heating

2: 86 percent / triethylamine; methanol / 24 h / 20 °C

3: 4-(dimethylamino)pyridine / acetonitrile / 1 h / 20 °C

4: 2,2'-azobis(isobutyronitrile); tri-n-butyltin hydride / toluene / 1 h / 85 °C

5: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With methanol; dmap; N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jm000209n

Reference yield:

: 233266-82-5
1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-D-ribo-pentofuranose

: 1054625-37-4
9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 25.5 h / Heating

2: 86 percent / triethylamine; methanol / 24 h / 20 °C

3: 4-(dimethylamino)pyridine / acetonitrile / 1 h / 20 °C

4: 2,2'-azobis(isobutyronitrile); tri-n-butyltin hydride / toluene / 1 h / 85 °C

5: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With methanol; dmap; N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jm000209n