3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4-[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4(1H)-pyridinone

Base Information

Chemical Name:3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4-[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4(1H)-pyridinone
CAS No.:1236000-43-3
Molecular Formula:C₃₂H₃₀ClF₃N₂O₃
Molecular Weight:583.05
Hs Code.:

Synonyms:3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4-[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4(1H)-pyridinone

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Chemical Property of 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4-[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4(1H)-pyridinone

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Technology Process of 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4-[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4(1H)-pyridinone

There total 2 articles about 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4-[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 180160-91-2
4-(4-(trifluoromethoxy)phenyl)piperidine

: 1236001-02-7
4'-[5-chloro-2-(hydroxymethyl)-6-methyl-4-oxo-1,4-dihydro-3-pyridinyl]-4-biphenyl-carbaldehyde

: 1236000-43-3
3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4-[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4(1H)-pyridinone

Guidance literature:: 4-(4-(trifluoromethoxy)phenyl)piperidine; 4'-[5-chloro-2-(hydroxymethyl)-6-methyl-4-oxo-1,4-dihydro-3-pyridinyl]-4-biphenyl-carbaldehyde; In tetrahydrofuran; 1,1-dichloroethane; for 0.25h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; 1,1-dichloroethane; at 20 ℃;

Reference yield:

: 1236001-07-2
3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4-pyridinyl bis(1-methylethyl)carbamate trifluoroacetate salt

: 1236000-43-3
3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4-[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4(1H)-pyridinone

Guidance literature:: 3-chloro-6-(hydroxymethyl)-2-methyl-5-{4'-[(4-{4[(trifluoromethyl)oxy]phenyl}-1-piperidinyl)methyl]-4-biphenylyl}-4-pyridinyl bis(1-methylethyl)carbamate trifluoroacetate salt; With hydrogenchloride; In methanol; water; for 3h; Reflux;

With sodium hydroxide; In water;