(E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile

Base Information

Chemical Name:(E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile
CAS No.:1416732-22-3
Molecular Formula:C₁₈H₁₂F₄N₆O
Molecular Weight:404.326
Hs Code.:

Synonyms:(E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile

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Chemical Property of (E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile

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Technology Process of (E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile

There total 5 articles about (E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 288-94-8
1H-tetrazole

: C₁₇H₁₀F₄N₂O

: 1416732-22-3
(E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 22h; Inert atmosphere;

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1416732-22-3
(E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

3.1: diethyl ether / 0 - 20 °C

4.1: sodium hydrogencarbonate; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 20 - 110 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 22 h / 65 °C / Inert atmosphere

With n-butyllithium; tetrabutylammomium bromide; copper; sodium hydrogencarbonate; potassium carbonate; palladium diacetate; In diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1416732-22-3
(E)-3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / hexane; diethyl ether / -70 - 20 °C

2: diethyl ether / 0 - 20 °C

3: sodium hydrogencarbonate; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 20 - 110 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 22 h / 65 °C / Inert atmosphere

With n-butyllithium; tetrabutylammomium bromide; sodium hydrogencarbonate; potassium carbonate; palladium diacetate; In diethyl ether; hexane; N,N-dimethyl-formamide;