1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

Base Information

Chemical Name:1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate
CAS No.:1301660-95-6
Molecular Formula:C₃₈H₃₈F₇N₃O₈
Molecular Weight:797.724
Hs Code.:

1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

Synonyms:1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

Suppliers and Price of 1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

There total 7 articles about 1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1301660-62-7
1,1-dimethylethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1-pyrrolidinecarboxylate

: 79-22-1
methyl chloroformate

: 1301660-95-6
1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

Guidance literature:: 1,1-dimethylethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1-pyrrolidinecarboxylate; With n-butyllithium; In tetrahydrofuran; at -15 ℃; for 0.5h;

methyl chloroformate; In tetrahydrofuran; at -15 ℃; for 1h;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-95-6
1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: hydrogen / Raney-Ni / ethanol; water / 4 h

6.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

7.1: n-butyllithium / tetrahydrofuran / 0.5 h / -15 °C

7.2: 1 h / -15 °C

With dmap; osmium(VIII) oxide; n-butyllithium; water; hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-58-1
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-propenoate

: 1301660-95-6
1-(1,1-dimethylethyl) 3,3-dimethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3,3-pyrrolidinetricarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

2.1: hydrogen / Raney-Ni / ethanol; water / 4 h

3.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -15 °C

4.2: 1 h / -15 °C

With dmap; n-butyllithium; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; Raney-Ni; In tetrahydrofuran; ethanol; dichloromethane; water;