6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

Base Information

• Chemical Name: 6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile
• CAS No.: 171071-00-4
• Molecular Formula: C₁₈H₁₃N₃O
• Molecular Weight: 287.321
• Mol file: 171071-00-4.mol

Synonyms:6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

Chemical Property of 6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile

There total 2 articles about 6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

benzaldehyde (100-52-7) + p-aminobenzophenone (99-92-3) + ethyl 2-cyanoacetate (105-56-6) → 6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile (171071-00-4)

Guidance literature:

With ammonium acetate; In butan-1-ol; Reflux;

DOI:10.1016/j.bioorg.2021.104877

Reference yield:

ethyl benzylidenecyanoacetate (2025-40-3) + p-aminobenzophenone (99-92-3) → 6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile (171071-00-4)

Guidance literature:

With ammonium acetate; In ethanol; Heating;

DOI:10.1080/15257779508010701

Reference yield: 70.0%

6-(4-aminophenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile (171071-00-4) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[6-(4-amino-phenyl)-3-cyano-2-oxo-4-phenyl-2H-pyridin-1-yl]-tetrahydro-pyran-3-yl ester (171071-06-0)

Guidance literature:

With potassium hydroxide; In water; acetone; Ambient temperature;

DOI:10.1080/15257779508010701

upstream raw materials:

ethyl benzylidenecyanoacetate

p-aminobenzophenone

benzaldehyde

ethyl 2-cyanoacetate

Downstream raw materials:

Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[6-(4-amino-phenyl)-3-cyano-2-oxo-4-phenyl-2H-pyridin-1-yl]-tetrahydro-pyran-3-yl ester

Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[6-(4-amino-phenyl)-3-cyano-2-oxo-4-phenyl-2H-pyridin-1-yl]-tetrahydro-pyran-3-yl ester