2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

Base Information

Chemical Name:2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate
CAS No.:1381841-39-9
Molecular Formula:C₂₇H₃₄F₂N₆O₅S
Molecular Weight:592.667
Hs Code.:

2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

Synonyms:2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

Suppliers and Price of 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

There total 23 articles about 2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₈F₂N₆O₅S

: 1381841-39-9
2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

Guidance literature:: With iodine; In methanol; at 60 ℃; for 4h;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 145783-15-9
4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine

: 1381841-39-9
2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; sodium iodide / 1,4-dioxane / 7 h / 120 °C

2.1: sodium nitrite / water; acetic acid; ethyl acetate / 30 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

4.1: triethylamine / acetonitrile / 0.5 h / 20 °C

4.2: 2 h / 20 °C

5.1: iodine / methanol / 4 h / 60 °C

With iodine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 866551-95-3
ethyl 2-(6-(benzyloxycarbonylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy) acetate

: 1381841-39-9
2-((1S,2S,3S,4R)-4-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl)oxy)ethyl butyrate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium borohydride / tetrahydrofuran / 5 h / 0 °C

2.1: 5%-palladium/activated carbon / methanol / 1 h / 20 °C

3.1: triethylamine; sodium iodide / 1,4-dioxane / 7 h / 120 °C

4.1: sodium nitrite / water; acetic acid; ethyl acetate / 30 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h

6.1: triethylamine / acetonitrile / 0.5 h / 20 °C

6.2: 2 h / 20 °C

7.1: iodine / methanol / 4 h / 60 °C

With lithium borohydride; 5%-palladium/activated carbon; iodine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050