(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester

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Chemical Name:(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester
CAS No.:145452-12-6
Molecular Formula:C₃₅H₄₉N₃O₆
Molecular Weight:607.791
Hs Code.:

(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester

Synonyms:(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester

There total 32 articles about (S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145452-09-1
(S)-2-tert-Butoxycarbonylamino-2-[(R)-5-isopropyl-5-(3-methyl-but-2-enyl)-4-oxo-4,5-dihydro-1H-pyrrol-3-yl]-3-phenyl-propionic acid methyl ester

: 145452-12-6
(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / OsO₄, N-methylmorpholine N-oxide / acetone; H₂O / 24 h / Ambient temperature

2: 100 percent / NaIO₄ / tetrahydrofuran; H₂O / 1 h / Ambient temperature

3: toluene / 0.25 h

4: potassium hexamethyldisilazide / toluene; tetrahydrofuran / 0.17 h / Ambient temperature

With sodium periodate; osmium(VIII) oxide; potassium hexamethylsilazane; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1021/ja00101a017

Reference yield:

: (S)-2-[2-[(R)-4-((S)-1-tert-Butoxycarbonylamino-1-methoxycarbonyl-2-phenyl-ethyl)-2-isopropyl-3-oxo-2,3-dihydro-1H-pyrrol-2-yl]-eth-(Z)-ylideneamino]-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

: 145452-12-6
(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; for 0.166667h; Yield given; Ambient temperature;
DOI:10.1021/ja00101a017

Reference yield:

: 640-68-6,25609-85-2,7004-03-7,921-10-8
D-Val-OH

: 145452-12-6
(S)-2-tert-Butoxycarbonylamino-2-[(2S,5'S)-5'-isobutyl-2-isopropyl-5'-(3-methyl-but-2-enyl)-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-4-yl]-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 1.) aq. NaOH / 1.) ethanol, RT, 0.5 h, 2.) pentane, reflux, 48 h

2: CH₂Cl₂ / 336 h / 5 °C

3: 1.) potassium hexamethyldisilazide / 1.) THF, toluene, -78 deg C, 15 min, 2.) THF, toluene, -78 deg C, 30 min

4: 1N aq. NaOH / methanol / 16 h / Heating

5: K₂CO₃ / dimethylformamide / 1 h / 0 - 20 °C

6: 86 percent / dimedone, Pd(PPh₃)4 / tetrahydrofuran / 16 h / Ambient temperature

7: toluene

8: potassium hexamethyldisilazide / tetrahydrofuran / 0.17 h / Ambient temperature

9: 100 percent / OsO₄, N-methylmorpholine N-oxide / acetone; H₂O / 24 h / Ambient temperature

10: 100 percent / NaIO₄ / tetrahydrofuran; H₂O / 1 h / Ambient temperature

11: toluene / 0.25 h

12: potassium hexamethyldisilazide / toluene; tetrahydrofuran / 0.17 h / Ambient temperature

With sodium hydroxide; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hexamethylsilazane; potassium carbonate; dimedone; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ja00101a017